Open AccessDifferences in transcriptomic profiles of human cumulus cells isolated from oocytes at GV, MI and MII stages after in vivo and in vitro oocyte maturation
Author(s) -
Zamalou Gisèle Ouandaogo,
Nelly Frydman,
Laëtitia Hesters,
Saïd Assou,
D. Haouzi,
H. Déchaud,
R Frydman,
S. Hamamah
Publication year - 2012
Publication title -
human reproduction
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.446
H-Index - 226
eISSN - 1460-2350
pISSN - 0268-1161
DOI - 10.1093/humrep/des172
Subject(s) - oocyte , in vitro maturation , germinal vesicle , biology , andrology , transcriptome , polycystic ovary , in vivo , microarray , gene expression , microbiology and biotechnology , gene , endocrinology , genetics , embryo , medicine , insulin resistance , insulin
Oocyte maturation and competence to development depends on its close relationship with cumulus cells (CCs). However, the maturation conditions of human cumulus-oocyte complexes (COCs) might affect gene expression in both oocyte and CCs. We thus compared the transcriptome profiles of CCs isolated from in vivo and in vitro matured COCs at different nuclear maturation stages.
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