Open AccessTopiramate modulates post-infarction inflammation primarily by targeting monocytes or macrophages
Author(s) -
Zhaohui Wang,
Shiyuan Huang,
Yuling Sheng,
Peng Xu,
Hui Liu,
Nan Jin,
Jun Cai,
Yan-Wen Shu,
Ting Li,
Ping Li,
Cheng Fan,
Xiao-Fan Hu,
Wenyong Zhang,
Rui Long,
Ya You,
Caihong Huang,
Yi Song,
Chunhua Xiang,
Jue Wang,
Yong Yang,
Kun Liu
Publication year - 2017
Publication title -
cardiovascular research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.774
H-Index - 219
eISSN - 1755-3245
pISSN - 0008-6363
DOI - 10.1093/cvr/cvx027
Subject(s) - inflammation , medicine , topiramate , monocyte , immunology , myocardial infarction , cardiology , epilepsy , psychiatry
Monocytes/macrophages response plays a key role in post-infarction inflammation that contributes greatly to post-infarction ventricular remodelling and cardiac rupture. Therapeutic targeting of the GABAA receptor, which is enriched in monocytes/macrophages but not expressed in the myocardium, may be possible after myocardial infarction (MI).
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