Transient Ca2+ depletion of the sarcoplasmic reticulum at the onset of reperfusion | Zendy

Carlos A. Valverde | Zendy; Dmytro Kornyeyev | Zendy; Marcela Ferreiro | Zendy; Azadé D. Petrosky | Zendy; Alicia Mattiazzi | Zendy; Ariel L. Escobar | Zendy

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Transient Ca2+ depletion of the sarcoplasmic reticulum at the onset of reperfusion

Author(s) -

Carlos A. Valverde,

Dmytro Kornyeyev,

Marcela Ferreiro,

Azadé D. Petrosky,

Alicia Mattiazzi,

Ariel L. Escobar

Publication year - 2009

Publication title -

cardiovascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.774

H-Index - 219

eISSN - 1755-3245

pISSN - 0008-6363

DOI - 10.1093/cvr/cvp371

Subject(s) - endoplasmic reticulum , medicine , cardiology , myocardial stunning , stunning , transient (computer programming) , ischemia , endocrinology , chemistry , biochemistry , operating system , computer science

Myocardial stunning is a contractile dysfunction that occurs after a brief ischaemic insult. Substantial evidence supports that this dysfunction is triggered by Ca2+ overload during reperfusion. The aim of the present manuscript is to define the origin of this Ca2+ increase in the intact heart.

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