Visfatin induces human endothelial VEGF and MMP-2/9 production via MAPK and PI3K/Akt signalling pathways: novel insights into visfatin-induced angiogenesis | Zendy

Raghu Adya | Zendy; Bee K. Tan | Zendy; Anu Punn | Zendy; Jing Chen | Zendy; Harpal S. Randeva | Zendy

Open Access

Visfatin induces human endothelial VEGF and MMP-2/9 production via MAPK and PI3K/Akt signalling pathways: novel insights into visfatin-induced angiogenesis

Author(s) -

Raghu Adya,

Bee K. Tan,

Anu Punn,

Jing Chen,

Harpal S. Randeva

Publication year - 2007

Publication title -

cardiovascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.774

H-Index - 219

eISSN - 1755-3245

pISSN - 0008-6363

DOI - 10.1093/cvr/cvm111

Subject(s) - protein kinase b , angiogenesis , pi3k/akt/mtor pathway , vascular endothelial growth factor , mapk/erk pathway , endocrinology , medicine , vascular endothelial growth factor a , matrix metalloproteinase , signal transduction , chemistry , biology , microbiology and biotechnology , vegf receptors

Visfatin is a novel adipokine whose plasma concentrations are altered in obesity and obesity-related disorders; these states are associated with an increased incidence of cardiovascular disease. We therefore investigated the effect of visfatin on vascular endothelial growth factor (VEGF) and matrix metalloproteinases (MMP-2, MMP-9) production and the potential signalling cascades.

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