Assessing the Impact of a Vi-polysaccharide Conjugate Vaccine in Preventing Typhoid Infection Among Bangladeshi Children: A Protocol for a Phase IIIb Trial | Zendy

Katherine Theiss-Nyland | Zendy; Firdausi Qadri | Zendy; Rachel Colin-Jones | Zendy; Khalequ Zaman | Zendy; Farhana Khanam | Zendy; Xinxue Liu | Zendy; Merryn Voysey | Zendy; Arifuzzaman Khan | Zendy; Nazmul Hasan | Zendy; Fahim Ashher | Zendy; Yama F Mujadidi | Zendy; Andrew J. Pollard | Zendy; John D. Clemens | Zendy

Open Access

Assessing the Impact of a Vi-polysaccharide Conjugate Vaccine in Preventing Typhoid Infection Among Bangladeshi Children: A Protocol for a Phase IIIb Trial

Author(s) -

Katherine Theiss-Nyland,

Firdausi Qadri,

Rachel Colin-Jones,

Khalequ Zaman,

Farhana Khanam,

Xinxue Liu,

Merryn Voysey,

Arifuzzaman Khan,

Nazmul Hasan,

Fahim Ashher,

Yama F Mujadidi,

Andrew J. Pollard,

John D. Clemens

Publication year - 2019

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1093/cid/ciy1107

Subject(s) - typhoid fever , medicine , population , conjugate vaccine , environmental health , sanitation , public health , randomized controlled trial , protocol (science) , government (linguistics) , informed consent , cluster (spacecraft) , family medicine , pediatrics , alternative medicine , surgery , immunology , immunization , virology , nursing , pathology , antigen , linguistics , philosophy , computer science , programming language

Typhoid fever illnesses are responsible for more than 100 000 deaths worldwide each year. In Bangladesh, typhoid fever is endemic, with incidence rates between 292-395 per 100 000 people annually. While considerable effort has been made to improve access to clean water and sanitation services in the country, there is still a significant annual typhoid burden, which particularly affects children. A typhoid conjugate vaccine (Vi-TCV) was recently prequalified by the World Health Organization and recommended for use, and offers the potential to greatly reduce the typhoid burden in Bangladesh.

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