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A maximum pseudo-profile likelihood estimator for the Cox model under length-biased sampling
Author(s) -
ChiungYu Huang,
Jing Qin,
Dean Follmann
Publication year - 2012
Publication title -
biometrika
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.307
H-Index - 122
eISSN - 1464-3510
pISSN - 0006-3444
DOI - 10.1093/biomet/asr072
Subject(s) - censoring (clinical trials) , covariate , mathematics , estimator , statistics , proportional hazards model , econometrics , semiparametric model
This paper considers semiparametric estimation of the Cox proportional hazards model for right-censored and length-biased data arising from prevalent sampling. To exploit the special structure of length-biased sampling, we propose a maximum pseudo-profile likelihood estimator, which can handle time-dependent covariates and is consistent under covariate-dependent censoring. Simulation studies show that the proposed estimator is more efficient than its competitors. A data analysis illustrates the methods and theory.

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