Open AccessSynthesis and Identification of Some IminoFlavone derivatives with Evaluating of Their anti-oxidant activity
Author(s) -
Hala Shkyair Lihumis,
Saadon Abdulla Aowda
Publication year - 2020
Publication title -
iop conference series. materials science and engineering
Language(s) - English
Resource type - Journals
eISSN - 1757-899X
pISSN - 1757-8981
DOI - 10.1088/1757-899x/928/5/052018
Subject(s) - chalcone , chemistry , ascorbic acid , acetophenone , aldehyde , sodium hydroxide , condensation reaction , catalysis , aldol condensation , organic chemistry , aniline , aryl , dpph , condensation , yield (engineering) , nuclear chemistry , antioxidant , alkyl , physics , food science , materials science , metallurgy , thermodynamics
This work deals with the preparation of high yield iminoflavone compounds by simple through three parts: the first part of this study involves the preparation of (2,4-dihydroxychalcone) by the reaction of 2,4-dihydroxy acetophenone to condensation with aryl aldehyde by used of sodium hydroxide catalysts. The second part of this study includes the preparation of (minochalcone) with p-hydroxy aniline through the condensation reaction of 2,4-dihydroxy chalcone using the catalysts H2SO4,. The three part includes the preparation of (minochalcone) from substituted 2,4-diydroxyl iminochalcone in DMSO and in the presence of iodine.T LC to control the chemical reaction and to characterize the new derivatives using FT-IR, H1-NMR techniques. These synthesized compounds had also been assessed by (DPPH) method, the compounds (C1-C15) evaluated for their antioxidant activity, the compound C3 is strong antioxidant activity (IC50=18.07 μg/mL comparable to that of the well known (ascorbic acid) (IC50=31.95 μg/mL) used.