Open AccessEnhancing the Solubility of Ketoconazole via Pharmaceutical Cocrystal
Author(s) -
Indra Indra,
Fitri Miftahul Janah,
Ratih Aryani
Publication year - 2019
Publication title -
journal of physics conference series
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.21
H-Index - 85
eISSN - 1742-6596
pISSN - 1742-6588
DOI - 10.1088/1742-6596/1179/1/012134
Subject(s) - cocrystal , ketoconazole , solubility , differential scanning calorimetry , fourier transform infrared spectroscopy , melting point , chemistry , materials science , nuclear chemistry , chromatography , organic chemistry , chemical engineering , molecule , antifungal , medicine , thermodynamics , hydrogen bond , physics , dermatology , engineering
This present research is to synthesized and characterized cocrystal of ketoconazole through cocrystallization process in order to improve solubility properties of ketoconazole. Ketoconazole cocrystal synthesized by the slurry method and characterized using diffractometry (Powder X-Ray Diffraction), Thermogram (Differential Scanning Calorimetry), Microscopy (Polarizing microscope), FTIR spectroscopy and solubility analysis were performed to evaluate the cocrystal. The PXRD diffractogram of cocrystal ketoconazole is different compared to pure component. New peaks characteristic of cocrystal appear at a 2θ value of 16.94° and 24.58° In addition, synthesized cocrystal have unique habit crystal, melting point and FTIR spectrum compared to single component. The ketoconazole cocrystal from slurry method showed an improved solubility by 50 times compared to ketoconazole. This study showed that cocrystallization between ketoconazole and ascorbic acid were successfully formed and enhanced the solubility of the drug.
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