A Novel Single-Nucleotide Polymorphism in the Lactoferrin Gene Is Associated with Susceptibility to Diarrhea in North American Travelers to Mexico | Zendy

Mohamed A. Jamal | Zendy; Herbert L. DuPont | Zendy; ZhiDong Jiang | Zendy; Jaime BelkindGerson | Zendy; José F. Figueroa | Zendy; Lisa Y. Armitige | Zendy; Alexander K. Tsai | Zendy; Parvathy Nair | Zendy; F. J. Martinez-Sandoval | Zendy; Dongchuan Guo | Zendy; Peter Hayes | Zendy; Pablo C. Okhuysen | Zendy

Open Access

A Novel Single-Nucleotide Polymorphism in the Lactoferrin Gene Is Associated with Susceptibility to Diarrhea in North American Travelers to Mexico

Author(s) -

Mohamed A. Jamal,

Herbert L. DuPont,

ZhiDong Jiang,

Jaime BelkindGerson,

José F. Figueroa,

Lisa Y. Armitige,

Alexander K. Tsai,

Parvathy Nair,

F. J. Martinez-Sandoval,

Dongchuan Guo,

Peter Hayes,

Pablo C. Okhuysen

Publication year - 2007

Publication title -

clinical infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.44

H-Index - 336

eISSN - 1537-6591

pISSN - 1058-4838

DOI - 10.1086/512199

Subject(s) - diarrhea , single nucleotide polymorphism , genotype , lactoferrin , traveler's diarrhea , medicine , genotyping , immunology , virology , biology , gene , genetics

Diarrhea affects 40%-60% of travelers from industrialized nations who visit developing countries and is due to bacterial, viral, and parasitic agents. Lactoferrin is bactericidal to enteric pathogens, modulates the intestinal immune response, and is excreted in stool in response to infection with intestinal organisms. We investigated the impact that selected single-nucleotide polymorphisms (SNPs) in the human lactoferrin gene have on susceptibility to traveler's diarrhea.

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