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The effects of imidazoacridinones, new antineoplastic agents, on the human erythrocyte membrane
Author(s) -
Józwiak Zofia,
Pacholska Marzena,
Szwarocka Agnieszka
Publication year - 1997
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1080/15216549700204691
Subject(s) - erythrocyte membrane , membrane , membrane protein , electron paramagnetic resonance , chemistry , nuclear magnetic resonance spectroscopy , biophysics , biochemistry , biology , stereochemistry , nuclear magnetic resonance , physics
In the present study, the interactions of imidazoacridinones, C‐1311 and C‐1371 with human erythrocyte membranes were examined by electron spin resonance spectroscopy (ESR). It was observed that both compounds C‐1311 and C‐1371 preferentially bind to proteins producing the conformational changes of erythrocyte membrane skeletal proteins.