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Binding of the bovine caseinoglycopeptide to the platelet membrane glycoprotein GPIbα
Author(s) -
Chabance Béatrice,
Qian ZuYuan,
MiglioreSamour Danièle,
Jollès Pierre,
Fiat AnneMarie
Publication year - 1997
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1080/15216549700202451
Subject(s) - glycoprotein , platelet membrane glycoprotein , von willebrand factor , platelet , glycoprotein ib , chemistry , amino acid residue , biochemistry , binding site , residue (chemistry) , von willebrand disease , peptide sequence , biology , immunology , gene
The bovine caseinoglycopeptide (residues 106‐169), the C‐terminal part of κ‐casein, inhibited the von Willebrand factor‐dependent platelet aggregation in a dose‐dependent manner. An affinity matrix made of the caseinoglycopeptide selectively bound the platelet membrane glycoprotein GPIbα which contains the von Willebrand factor binding site. The amino acid residues of GPIbα participating in the caseinoglycopeptide binding were located after residue Glu90.