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Scorpion Venom Peptides without Disulfide Bridges
Author(s) -
Zeng XianChun,
Corzo Gerardo,
Hahin Richard
Publication year - 2005
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1080/15216540500058899
Subject(s) - venom , scorpion , disulfide bond , peptide , scorpion venoms , antimicrobial peptides , computational biology , chemistry , biochemistry , structural similarity , biology
Abstract Several hundred disulfide‐bridged neurotoxic peptides have been characterized from scorpion venom; however, only few scorpion venom peptides without disulfide bridges have been identified and characterized. These non‐disulfide‐bridged peptides (NDBPs) are a novel class of molecules because of their unique antimicrobial, immunological or cellular signaling activities. This review provides an overview of their structural simplicity, precursor processing, biological activities and evolution, and sheds insight into their potential clinical and agricultural applications. Based on their pharmacological activities and peptide size similarity, we have classified these peptides into six subfamilies.IUBMB Life, 57: 13‐21, 2005