Premium
The KRAB Domain of Zinc Finger Gene ZNF268: a Potential Transcriptional Repressor
Author(s) -
Sun Yan,
Gou Deming,
Liu Hui,
Peng Xiao,
Li Wenxin
Publication year - 2003
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1080/1521654031000110208
Subject(s) - zinc finger , repressor , gatad2b , lim domain , krüppel , ring finger domain , transcriptional regulation , gene , yy1 , biology , zinc finger nuclease , genetics , microbiology and biotechnology , transcription factor , gene expression , promoter
Abstract Nearly one‐third of Krupple‐type C2H2 zinc finger proteins have a krupple‐associated box (KRAB) domain, which may act as a transcriptional repressor. ZNF268, which was novelty isolated from early human embryo, is a typical krupple‐type C2H2 zinc finger protein with a conserved KRAB domain. In this report, the KRAB domain of ZNF268 is identified to localize in the nucleus and has transcriptional repressor activity. IUBMB Life, 55: 127‐131, 2003