Premium
Performance in the cross‐maze and slip funnel tests of four pairs of rat lines selectively bred for divergent alcohol drinking behavior
Author(s) -
SALIMOV R. M.,
MCBRIDE W. J.,
SINCLAIR J. D.,
LUMENG L.,
LI T.K.
Publication year - 1996
Publication title -
addiction biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.445
H-Index - 78
eISSN - 1369-1600
pISSN - 1355-6215
DOI - 10.1080/1355621961000124886
Subject(s) - alcohol , funnel , slip (aerodynamics) , chemistry , biology , psychology , physics , biochemistry , organic chemistry , thermodynamics
Abstract Alcohol naive rats from lines genetically selected for high and low alcohol drinking and founded on either Wistar (P/NP lines) and distinct heterogeneous stocks (AA/ANA and replicate HAD/LAD lines) were tested in the explorative cross‐maze and the inescapable slip funnel. Rats of the low alcohol‐consuming ANA, NP, LAD1 and LAD2 lines all exhibited a shorter latency before initiating exploration of the maze than did their high alcohol‐consuming counterparts (66, 51, 33 and 51% of the values for AA, P, HAD1 and HAD2 lines, respectively). Significant line differences were also found with the slip funnel test (AA > ANA for time in a sprawling posture; P > NP but HAD1 < LAD1 and HAD2 < LAD2 for time escaping), but the directions of line differences were not consistently related to those in alcohol drinking.