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Barbiturate withdrawal—a nomogram for supplementary dosing after the phenobarbitone loading technique
Author(s) -
BUCKLEY NICHOLAS A.,
FOY AIDAN
Publication year - 1995
Publication title -
drug and alcohol review
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.018
H-Index - 74
eISSN - 1465-3362
pISSN - 0959-5236
DOI - 10.1080/09595239500185521
Subject(s) - dosing , barbiturate , nomogram , medicine , anesthesia , pharmacology
Abstract A case of a woman who presented with a multiple drug overdose and then subsequently had a withdrawal syndrome complicated by seizures and delirium highlights the seriousness of the barbiturate withdrawal syndrome. The patient had a short elimination half‐life for phenobarbitone and required supplementary phenobarbitone doses to prevent and treat these complications. We have devised a nomogram which in conjunction with serum levels allows a rapid determination of whether and how much supplementary doses are required during barbiturate withdrawal.

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