Promoter-specific hypoacetylation of X-inactivated genes | Zendy

Sandra L. Gilbert | Zendy; Phillip A. Sharp | Zendy

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Promoter-specific hypoacetylation of X-inactivated genes

Author(s) -

Sandra L. Gilbert,

Phillip A. Sharp

Publication year - 1999

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.96.24.13825

Subject(s) - promoter , gene , acetylation , methylation , histone , promoter activity , genetics , biology , microbiology and biotechnology , chemistry , gene expression

The histone H4 acetylation status of the active X (Xa) and inactive X (Xi) chromosomes was investigated at the level of individual genes. A moderate level of acetylation was observed along the lengths of genes on both the Xi and Xa, regardless of their X inactivation status. However, this moderate level of acetylation was modified specifically in promoter regions. Transcriptionally active genes showed elevated levels of acetylation at their promoters on both the Xi and Xa. In contrast, promoters of X-inactivated genes were markedly hypoacetylated, which coincided with the methylation of adjacent CG dinucleotides. This promoter-specific hypoacetylation may be a key component of an X inactivation machinery that operates at the level of individual genes.

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