Nerve growth factor increases activity of ornithine decarboxylase in rat brain | Zendy

Michael E. Lewis | Zendy; J. Lakshmanan | Zendy; K. Nagaiah | Zendy; Paul C. MacDonnell | Zendy; Gordon Guroff | Zendy

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Nerve growth factor increases activity of ornithine decarboxylase in rat brain

Author(s) -

Michael E. Lewis,

J. Lakshmanan,

K. Nagaiah,

Paul C. MacDonnell,

Gordon Guroff

Publication year - 1978

Publication title -

proceedings of the national academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.011

H-Index - 771

eISSN - 1091-6490

pISSN - 0027-8424

DOI - 10.1073/pnas.75.2.1021

Subject(s) - ornithine decarboxylase , medicine , endocrinology , ornithine , ornithine decarboxylase antizyme , nerve growth factor , enzyme , carboxy lyases , biology , chemistry , growth factor , biochemistry , amino acid , arginine , receptor

Intraventricular administration of nanogram quantities of nerve growth factor to adult rats results in a marked increase in the activity of ornithine decarboxylase (L-ornithine carboxy-lyase, EC 4.1.1.17) in the brain. The increase occurs in all major brain regions and the activity is maximal by 7.5 hr after administration. The enzyme response to nerve growth factor increases in magnitude during maturation; the relative increase in ornithine decarboxylase activity in adult animals is much greater than that in young. Neither insulin nor bovine growth hormone was able to increase ornithine decarboxylase activity to the same extent as did nerve growth factor. When brain was separated into neuronal- and glial-enriched fractions, induction of ornithine decarboxylase was found in both, but a greater increase was observed in the glial fraction.

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