Open AccessDevelopment of the Autonomic Nervous System: Clinical Implications
Author(s) -
Frances Lefcort
Publication year - 2020
Publication title -
seminars in neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.048
H-Index - 71
eISSN - 1098-9021
pISSN - 0271-8235
DOI - 10.1055/s-0040-1713926
Subject(s) - autonomic nervous system , medicine , neuroscience , dysautonomia , rett syndrome , nervous system , central nervous system , congenital central hypoventilation syndrome , familial dysautonomia , disease , hypoventilation , pathology , biology , gene , respiratory system , heart rate , biochemistry , blood pressure
Investigations of the cellular and molecular mechanisms that mediate the development of the autonomic nervous system have identified critical genes and signaling pathways that, when disrupted, cause disorders of the autonomic nervous system. This review summarizes our current understanding of how the autonomic nervous system emerges from the organized spatial and temporal patterning of precursor cell migration, proliferation, communication, and differentiation, and discusses potential clinical implications for developmental disorders of the autonomic nervous system, including familial dysautonomia, Hirschsprung disease, Rett syndrome, and congenital central hypoventilation syndrome.