Open AccessC–H Insertion Reactions of Donor/Donor Carbenes: Inception, Investigation, and Insights
Author(s) -
Jared T. Shaw
Publication year - 2020
Publication title -
synlett
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.712
H-Index - 133
eISSN - 1437-2096
pISSN - 0936-5214
DOI - 10.1055/s-0039-1691738
Subject(s) - chemistry , insertion reaction , natural product , combinatorial chemistry , selectivity , stereochemistry , organic chemistry , catalysis
Insertion reactions of donor/donor carbenes have emerged from obscurity to become a versatile method for the synthesis of a variety of cyclic structures with excellent control of diastereo- and enantioselectivity. This Account describes the origin of this project as part of a natural product synthesis and the ensuing decade of reaction development that has resulted in new asymmetric methods as well as intriguing tangential observations.