Open AccessEarly Postnatal IGF-1 and IGFBP-1 Blood Levels in Extremely Preterm Infants: Relationships with Indicators of Placental Insufficiency and with Systemic Inflammation
Author(s) -
Alan Leviton,
Elizabeth N. Allred,
Rai. Fichorova,
Deborah K. VanderVeen,
T. Michael O’Shea,
Karl Kuban,
Olaf Dammann
Publication year - 2019
Publication title -
american journal of perinatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.793
H-Index - 67
eISSN - 1098-8785
pISSN - 0735-1631
DOI - 10.1055/s-0038-1677472
Subject(s) - medicine , placental insufficiency , gestation , endocrinology , placenta , gestational age , insulin like growth factor , growth factor , inflammation , pregnancy , fetus , neurotrophin , placental growth factor , vascular endothelial growth factor , receptor , biology , genetics , vegf receptors
To evaluate to what extent indicators of placenta insufficiency are associated with low concentrations of insulin-like growth factor 1 (IGF-1) and IGF-1-binding protein-1 (IGFBP-1) in neonatal blood, and to what extent the concentrations of these growth factors are associated with concentrations of proteins with inflammatory, neurotrophic, or angiogenic properties.