Serologic evidence that Scianna null (Sc:−1,−2) red cells lack multiple high‐frequency antigens | Zendy

Devine P. | Zendy; Dawson F.E. | Zendy; Motschman T.L. | Zendy; Skradski K.J. | Zendy; Orsini L. | Zendy; Moulds J.J. | Zendy; Taswell H.F. | Zendy

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Serologic evidence that Scianna null (Sc:−1,−2) red cells lack multiple high‐frequency antigens

Author(s) -

Devine P.,

Dawson F.E.,

Motschman T.L.,

Skradski K.J.,

Orsini L.,

Moulds J.J.,

Taswell H.F.

Publication year - 1988

Publication title -

transfusion

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.045

H-Index - 132

eISSN - 1537-2995

pISSN - 0041-1132

DOI - 10.1046/j.1537-2995.1988.28488265264.x

Subject(s) - serology , antigen , medicine , immunology , antibody

Sera from three unrelated persons whose red cells (RBC) had the common Scianna phenotype (Sc:1,−2) contained IgG alloantibodies directed against high‐frequency RBC antigens. In each case, sera or eluates or both failed to react only with Scianna null (Sc:−1,−2) cells, although an eluate from one person was compatible with a sibling's Sc:1,−2 cells. Cross‐testing cells with sera or eluates, or both, from the three persons revealed no mutual compatibility. These studies show the existence of three additional RBC antigens phenotypically related to the Scianna blood group system. Sc:−1,−2 cells lack these antigens, which indicates that Scianna null cells lack multiple high‐frequency antigens.

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