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Immune anti‐A 1 in A 2 recipients of kidneys from group O donors
Author(s) -
Bracey A. W.,
Buren C.
Publication year - 1986
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1046/j.1537-2995.1986.26386209389.x
Subject(s) - abo blood group system , hemolysis , antibody , red cell , immunology , medicine , immune system , antigen , kidney , kidney transplantation , transplantation , red blood cell , isoantibodies
Antibodies specific for recipient red cell antigens have been demonstrated in patients who receive organs from ABO unmatched donors. In some cases, severe but self‐limited hemolysis has been associated with the development of posttransplantation antibodies. We report a case in which an A 2 recipient of a kidney from a group O donor formed anti‐A 1 antibody which reacted with homologous red cells. The patient developed a delayed hemolytic transfusion reaction. A radiochromium survival study revealed decreased survival of A 1 red cells. A broader specificity of the antibody was not shown during follow‐up. The anti‐A 1 was not detected in a sample tested 6 months after the initial study. It is probable that the anti‐A 1 noted in this case was formed by passenger lymphocytes. A 2 patients who develop anti‐A 1 after renal transplantation should be transfused with red cells negative for A 1 .