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Anti‐M causing delayed hemolytic transfusion reaction
Author(s) -
Alperin J. B.,
Riglin H.,
Branch D. R.,
Gallagher M. T.,
Petz L. D.
Publication year - 1983
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1046/j.1537-2995.1983.23483276867.x
Subject(s) - hemolysis , phagocytosis , red cell , antibody , pathogenesis , immunology , in vitro , transfusion reaction , monocyte , medicine , macrophage , chemistry , biochemistry
A 52‐year‐old gravida 1, para 1 woman with M‐ red cells experienced a delayed hemolytic transfusion reaction and exhibited an anti‐M antibody following the infusion of four units of M+ red cells. Measurements of erythrocyte survival using 51 Cr‐labeled donor M+ and M‐red cells and in vitro studies of monocyte‐macrophage phagocytosis of sensitized reagent red cells implicate anti‐M in the pathogenesis of hemolysis.