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Pharmacokinetics of Nafamostat Mesilate During Continuous Hemodiafiltration with a Polyacrylonitrile Membrane
Author(s) -
Nakae Hajime,
Tajimi Kimitaka
Publication year - 2003
Publication title -
therapeutic apheresis and dialysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.415
H-Index - 53
eISSN - 1744-9987
pISSN - 1744-9979
DOI - 10.1046/j.1526-0968.2003.00088.x
Subject(s) - medicine , pharmacokinetics , polyacrylonitrile , plasma concentration , anesthesia , membrane , positive correlation , urology , gastroenterology , biochemistry , chemistry , organic chemistry , polymer
Abstract: We studied the pharmacokinetics of nafamostat mesilate (NM) used as an anticoagulant in continuous hemodiafiltration (CHDF) with a polyacrylonitrile (PAN) membrane used as the hemofilter. Six patients undergoing CHDF for multiple organ dysfunction syndrome (MODS) were chosen as subjects. The inlet NM concentration measured 24 h after the start of CHDF was significantly greater than that after 1 h ( P = 0.0431). No significant difference was observed between the outlet NM concentration and the ultrafilter concentration at 1 h or 24 h after the start of CHDF. However, concentrations at 24 h differed significantly from concentrations at 1 h at all sites. Significant correlation was observed between the dose of NM and the outlet NM concentration ( P = 0.0475). No statistical correlation was observed between the dose of catecholamines and the outlet NM concentration ( P = 0.0985). This study is the first to disclose a mild but significant time‐dependent serum NM concentration in patients with MODS.