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At Least Thirty‐Four Days of Animal Continuous Perfusion by a Newly Developed Extracorporeal Membrane Oxygenation System without Systemic Anticoagulants
Author(s) -
Nishinaka Tomohiro,
Tatsumi Eisuke,
Taenaka Yoshiyuki,
Katagiri Nobumasa,
Ohnishi Hiroyuki,
Shioya Kyoko,
Fukuda Toshihide,
Oshikawa Mitsuo,
Sato Koichi,
Tsukiya Tomonori,
Homma Akihiko,
Takewa Yoshiaki,
Takano Hisateru,
Sato Masaki,
Kashiwabara Susumu,
Tanaka Hidenori,
Sakai Kazunari,
Matsuda Toshiaki
Publication year - 2002
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1046/j.1525-1594.2002.06886_3.x
Subject(s) - oxygenator , extracorporeal membrane oxygenation , cardiopulmonary bypass , thrombus , membrane oxygenator , medicine , heparin , perfusion , extracorporeal circulation , extracorporeal , biomedical engineering , materials science , anesthesia , surgery , cardiology
Abstract: We developed an extracorporeal membrane oxygenation (ECMO) system with high antithrombogenicity and durability characteristics for prolonged continuous cardiopulmonary support. The oxygenator consists of a special hollow‐fiber‐type polyolefin gas‐exchange membrane, which has an ultrathin dense layer in contact with the blood, in order to prevent plasma leakage during protracted use (Platinum Cube NCVC). The centrifugal pump (RotaFlow) is free of seals. The entire blood‐contacting surface of the system is coated with a newly developed heparin material (Toyobo‐NCVC coating). We performed a venoarterial bypass in a goat, and the ECMO system was driven for 34 days without systemic anticoagulants. Plasma leakage from the oxygenator did not occur, and sufficient gas exchange performance was maintained. Thrombus formation was hardly observed in the ECMO system except in the casing margins of the oxygenator. This ECMO system showed potential for long‐term cardiopulmonary support with minimal or no use of systemic anticoagulants.