Premium
Minocycline Hypersensitivity Syndrome with Hypotension Mimicking Septic Shock
Author(s) -
Colvin Jill H.,
Sheth Anita P.
Publication year - 2001
Publication title -
pediatric dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.542
H-Index - 73
eISSN - 1525-1470
pISSN - 0736-8046
DOI - 10.1046/j.1525-1470.2001.01931.x
Subject(s) - minocycline , medicine , acne , discontinuation , septic shock , hypersensitivity reaction , dermatology , adverse effect , anesthesia , delayed hypersensitivity , tetracycline , shock (circulatory) , surgery , antibiotics , sepsis , immunology , pharmacology , immune system , microbiology and biotechnology , biology
Minocycline is a semisynthetic tetracycline derivative that is often used in the treatment of acne vulgaris. A serious but rare adverse effect caused by minocycline therapy is a hypersensitivity syndrome (HS), consisting of fever, skin eruption, and internal organ involvement that begins within 8 weeks of therapy initiation. We report a case of minocycline HS with unique features, namely, associated hypotension, and a rebound of the cutaneous eruption upon discontinuation of systemic steroids.