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Interferons Suppress Nerve Growth Factor Synthesis as a Result of Interference with Cell Growth in Astrocytes Cultured from Neonatal Mouse Brain
Author(s) -
Awatsuji Hirofumi,
Furukawa Yoshiko,
Hirota Masao,
Furukawa Shoei,
Hayashi Kyozo
Publication year - 1995
Publication title -
journal of neurochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.75
H-Index - 229
eISSN - 1471-4159
pISSN - 0022-3042
DOI - 10.1046/j.1471-4159.1995.64041476.x
Subject(s) - nerve growth factor , dna synthesis , astrocyte , biology , fibroblast growth factor , cell growth , secretion , growth factor , medicine , cell culture , microbiology and biotechnology , endocrinology , interferon , basic fibroblast growth factor , dna , immunology , central nervous system , biochemistry , receptor , genetics
Abstract: Interferon (IFN)‐β and IFN‐γ inhibited the DNA synthesis and nerve growth factor (NGF) synthesis in growing astrocytes cultured from neonatal mouse brain, but they did not affect the NGF synthesis in quiescent astrocytes. IFN‐β and IFN‐γ also inhibited the enhanced DNA synthesis and NGF synthesis in growing astrocytes after the administration of basic fibroblast growth factor. These results indicated that NGF synthesis in astrocytes is regulated by IFNs associated with cell growth. The mechanism of IFN action on NGF synthesis/secretion is unknown, but the results that their effects last long after IFN removal from the cultures present the possibility that IFNs destabilize NGF mRNA.