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A quantitative analysis of perineurial cell basement membrane collagen IV, laminin and fibronectin in diabetic and non‐diabetic human sural nerve
Author(s) -
Hill R. E.,
Williams P. E.
Publication year - 2002
Publication title -
journal of anatomy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.932
H-Index - 118
eISSN - 1469-7580
pISSN - 0021-8782
DOI - 10.1046/j.1469-7580.2002.00083.x
Subject(s) - laminin , basement membrane , fibronectin , sural nerve , medicine , immunohistochemistry , type iv collagen , pathology , anatomy , cell , chemistry , biochemistry
The thickness of the perineurial cell basement membrane was examined in diabetic and non‐diabetic human sural nerve. A significant increase in thickness was found in the diabetic group. The nature of this thickening was investigated using immunohistochemistry and image analysis in order to semi‐quantify three of the major intrinsic components of the perineurial cell basement membrane: collagen IV, laminin and fibronectin. Amounts of all three components were shown to be increased in the diabetic group, but not significantly so. However, significant linear correlations between fascicle size and perineurial collagen IV, laminin and fibronectin were identified in both diabetic and non‐diabetic nerve.