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Inhibition of proliferation of a colon cancer cell line by indole‐3‐carbinol
Author(s) -
Frydoonfar H. R.,
McGrath D. R.,
Spigelman A. D.
Publication year - 2002
Publication title -
colorectal disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.029
H-Index - 89
eISSN - 1463-1318
pISSN - 1462-8910
DOI - 10.1046/j.1463-1318.2002.00346.x
Subject(s) - cell growth , medicine , cruciferous vegetables , colorectal cancer , cell culture , cell , indole test , cancer research , cancer , oncology , biochemistry , biology , genetics
Objective To observe the effect of Indole‐3‐carbinol (I3C), a naturally occurring component of cruciferous vegetables, on cell proliferation of a colon cancer cell line. Methods Cell proliferation was measured using three different methods; 3 H‐thymidine incorporation, cell count and colourimetric assay. Results Each method of measurement revealed that I3C significantly reduced cell proliferation at concentrations of > 0.1 m M . Conclusion The present study demonstrates for the first time the capacity of indole‐3‐carbinol to inhibit cell proliferation of a colon cancer cell line.