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Role of Vagal Control in Vasovagal Syncope
Author(s) -
SUZUKI MASARU,
HORI SHINGO,
NAKAMURA IWAO,
NAGATA SHINYA,
TOMITA YUTAKA,
AIKAWA NAOKI
Publication year - 2003
Publication title -
pacing and clinical electrophysiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.686
H-Index - 101
eISSN - 1540-8159
pISSN - 0147-8389
DOI - 10.1046/j.1460-9592.2003.00096.x
Subject(s) - vasovagal syncope , medicine , syncope (phonology) , heart rate variability , cardiology , tilt (camera) , tilt table test , anesthesia , heart rate , vagus nerve , blood pressure , rr interval , stimulation , mechanical engineering , engineering
SUZUKI, M., et al .: Role of Vagal Control in Vasovagal Syncope.The vasovagal reaction is thought to be caused by sympathetic withdrawal and vagal augmentation. While measurements of muscle sympathetic nerve activity support sympathetic withdrawal in tilt induced syncope, the results of previous attempts to quantify vagal control using spectral analyses of heart rate variability (HRV) remain controversial. The sampling period used in the HRV studies is related to the discordant results. In the present study, HRV was computed every second using wavelet transformation to clarify the role of vagal control in tilt induced syncope during the 80‐degree head‐up tilt test (positive: 10 patients with vasovagal syncope; negative: 10 patients with vasovagal syncope, and 10 control subjects). Autonomic modulations were assessed using the absolute power of the low frequency (LF) (0.04–0.15 Hz) and high frequency (HF) (0.15–2.00 Hz) oscillatory components of R‐R variability. Although the LF did not change during the tilt procedure, a decrease in the systolic arterial pressure (SAP) and increases in the R‐R interval and HF were observed for the last 30 seconds before the tilt induced syncope in the tilt‐positive group. Analyzing the hemodynamic measurements and spectral indices for the last 5 minutes preceding the tilt induced syncope, the study found that the SAP, R‐R interval, and HF changed simultaneously during the 30‐second period immediately before the tilt induced syncope. Further, the HF was positively correlated with the R‐R interval and negatively correlated with the SAP. In conclusion, continuous spectral analysis of the R‐R interval demonstrated increased vagal influence on the heart in tilt induced syncope. (PACE 2003; 26[Pt. I]:571–578)