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Inflammatory changes in the lungs of premature infants with symptomatic patent ductus arteriosus
Author(s) -
Nakamura Toshihiko,
Takasaki Jiro,
Ogawa Yunosuke
Publication year - 2002
Publication title -
pediatrics international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.49
H-Index - 63
eISSN - 1442-200X
pISSN - 1328-8067
DOI - 10.1046/j.1442-200x.2002.01588.x
Subject(s) - medicine , ductus arteriosus , cardiology , pediatrics
AbstractBackground: The aim of the study was to observe the inflammatory changes during the therapy for symptomatic patentductus arteriosus (sPDA).Methods: We investigated biochemically the sample of the tracheobroncheal aspirates (TA) from 11 intubated prematureinfants. Three i.v. doses of indomethacin (0.2 mg/kg) were administered with 24‐h intervals. The samples were dividedinto two groups, the effective occasions ( n = 10) and non‐effective occasions ( n = 6). Theamounts of myeloperoxidase (MPO), soluble L‐selectin (sL‐selectin) in TA, and the polymorphonuclear leukocytes (PMN) of peripheralblood stream and TA were analyzed before and after treatment of sPDA with indomethacin.Results: In effective occasions, there were significant decreases of peripheral PMN and MPO and PMN in TA. However, thisgroup had a significant increase of sL‐selectin. In non‐effective occasions, five out of six samples had decreases of MPO and PMNin TA, but not significantly. In contrast, there was a significant decrease of sL‐selectin.Conclusion: These data suggested that anti‐inflammatory change after closure of sPDA may be caused by not only indomethacinitself, but also ductal closure itself. However, futher study is necessary to clarify the relationship between the closure of theductus itself and anti‐inflammatory action in the lung.