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Expression of CD34 antigen in testicular mixed germ cell tumor
Author(s) -
Hamazaki Shuji,
Okada Shigeru
Publication year - 2003
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1046/j.1440-1827.2003.01566.x
Subject(s) - yolk sac , cd34 , pathology , biology , germ cell , immunostaining , choriocarcinoma , seminoma , immunohistochemistry , embryonal carcinoma , embryo , cellular differentiation , medicine , stem cell , microbiology and biotechnology , chemotherapy , biochemistry , genetics , gene
The expression of CD34 was investigated in 14 cases of testicular mixed germ cell tumor to elucidate the relationship between its expression and histological patterns. Seven of 12 yolk sac tumor components were focally immunoreactive for anti‐CD34 antibody. Of these, five showed focal but intense CD34 staining, while the remaining two tumors showed weak staining in small clusters or isolated tumor cells. Positive immunostaining for CD34 was seen predominantly in solid and reticular patterns of the yolk sac tumor components. Seminoma, embryonal carcinoma, and choriocarcinoma components were invariably negative for CD34. If present, immunoreactivity for CD34 in yolk sac tumors is focal and variable, but useful for the distinction from other germ cell tumors.