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Colonic intra‐epithelial carcinoma occurring in a hyperplastic polyp via a serrated adenoma
Author(s) -
Tanaka Masanori,
Kusumi Tomomi,
Sasaki Yoshio,
Yamagata Kazufumi,
Ichinohe Hisato,
Nishida Jun,
Kudo Hajime
Publication year - 2001
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1046/j.1440-1827.2001.01177.x
Subject(s) - hyperplastic polyp , dysplasia , pathology , adenoma , carcinoma , tubular adenoma , epithelial dysplasia , medicine , hyperplasia , colorectal cancer , colonoscopy , cancer
We present a case of intra‐epithelial carcinoma occurring in a serrated adenoma of the colon. The pedunculated polyp, which measured 12 × 10 × 6 mm, was endoscopically removed from the ascending colon of a 78‐year‐old woman. Histologically, the polyp mainly consisted of serrated adenomatous glands, and had foci of intra‐epithelial carcinoma at the top. Hyperplastic (metaplastic) areas were also present in both borders between the serrated adenomatous area and the surrounding normal mucosa. A sequential increase in the degree of dysplasia, and in the number of nuclei positively reactive for Ki‐67 and p53 was evident from the hyperplastic areas toward the foci of carcinoma. The polyp described here may represent a carcinogenic potential of hyperplastic polyp via serrated adenoma.