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Effects of subtotal resection of the fundus on development of intestinal metaplasia induced by X‐ray irradiation in Donryu rats
Author(s) -
Kinoshita Ken,
Watanabe Hiromitsu,
Ando Yasumi,
Katayama Masanori,
Yamamoto Hideki,
Hirano Nobuyuki,
Yoshikuni Susumu,
Yamamoto Takahiro
Publication year - 2000
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1046/j.1440-1827.2000.01128.x
Subject(s) - fundus (uterus) , intestinal metaplasia , resection , medicine , pathology , metaplasia , gastroenterology , surgery , dysplasia
Eight‐week‐old male Crj:Donryu rats underwent subtotal resection of the fundus and X‐ray irradiation. Six months later the animals were autopsied and examined for intestinal metaplasia. The numbers of alkaline phosphatase‐positive foci with the two treatments in combination were significantly increased, compared to the operation alone and non‐treatment groups. Histologically assessed intestinal metaplasia was also increased in the combined treatment group. In conclusion, subtotal resection of the fundus combined with X‐ray irradiation is an effective induction protocol for intestinal metaplasia.