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Role of β 2 integrins in glomerular leucocytes in Henoch‐Schoenlein purpura nephritis: an age‐matched comparative study with immunoglobulin A nephropathy
Author(s) -
JIN Shilan,
OOTAKA Tetsuya,
SOMA Jun,
SATO Toshinbbu,
SATO Hiroshi,
ITO Sadayoshi,
SAITO Takao
Publication year - 2002
Publication title -
nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.752
H-Index - 61
eISSN - 1440-1797
pISSN - 1320-5358
DOI - 10.1046/j.1440-1797.2002.00108.x
Subject(s) - medicine , nephritis , lupus nephritis , nephropathy , glomerulonephritis , infiltration (hvac) , pathology , immunology , renal function , peritubular capillaries , endocrinology , kidney , diabetes mellitus , physics , disease , thermodynamics
SUMMARY: A comparative immunohistological study was performed for the glomerular deposition of complements (C1q and C3c), fibrin/fibrinogen‐related antigen (FRA), the expression of intercellular adhesion molecule‐1 (ICAM‐1), and the infiltration of leucocytes bearing β 2 integrins (leucocyte function associated antigen‐1 (LFA‐1), complement receptor 3 (CR3) and complement receptor 4 (CR4)) on renal biopsy specimens from 49 cases with Henoch‐Schoenlein purpura nephritis (HSPN), and 49 age‐matched cases with immunoglobulin A nephropathy (IgAN). the glomerular expression of ICAM‐1 was signifcantly correlated with the glomerular infiltration of leucocyte function associated antigen (LFA)‐1 + leucocytes in both diseases, and with that of CR3 + leucocytes in HSPN. the expression of ICAM‐1 was closely localized with the infiltration of LFA‐1 + leucocytes in the study with double immunostaining. the incidence and intensity of glomerular deposition of FRA were significantly higher in HSPN than in IgAN ( P < 0.001), and those of C3c were significantly lower in HSPN than in IgAN ( P < 0.001). the glomerular deposition of FRA was significantly correlated with the glomerular infiltration of CR4 + leucocytes in HSPN ( P <0.05) but not in IgAN. In contrast, the glomerular deposition of C3c was significantly correlated with the glomerular infiltration of CR4 + leucocytes in IgAN ( P <0.05), but not in HSPN. Studies with double immunostaining revealed a close association of CR4 + leucocytes with FRA deposition in HSPN and with C3c deposition in IgAN, respectively. the number of glomerular leucocytes bearing β 2 integrins was significantly correlated with urinary protein at the time of renal biopsy in both diseases. These results suggested the differential roles of β 2 integrins in the induction of glomerular injury in HSPN and IgAN. the ICAM‐1/LFA‐1 interaction may commonly be involved in the glomerular infiltration of leucocytes in both diseases. the ICAM‐1/CR3 interaction may be involved only in HSPN. Complement receptor 4 may function as a fibrin/fibrinogen receptor in HSPN, while CR4 may function as a complement receptor in IgAN.