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Molecular pathogenesis of viral hepatitis
Author(s) -
Locarnini Stephen
Publication year - 2000
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1046/j.1440-1746.2000.02265.x
Subject(s) - medicine , pathogenesis , immunology , viral replication , disease , viral hepatitis , virology , viral pathogenesis , viral disease , virus , pathology
The global burden of chronic liver disease caused by persistent infection with hepatitis B and C viruses has meant the urgent development of therapeutic strategies designed to control active replication and therefore prevent subsequent clinical sequelae. Advances in these therapeutic strategies are now clearly happening, mainly as a consequence of a better understanding of the viral life cycle and the unique pathogenesis of each disease. Further progress should continue as further insights into the virus–cell relationship are derived, which will sharpen attention on specific viral targets as well as shift and enhance host cytokine responses.