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Effect of pancreastatin on cerulein‐stimulated pancreatic blood flow and exocrine secretion in anaesthetized rats
Author(s) -
Migita Yoshikatsu,
Nakano Itsuro,
Goto Masayoshi,
Ito Tetsuhide,
Nawata Hajime
Publication year - 1999
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1046/j.1440-1746.1999.01918.x
Subject(s) - pancreatic juice , medicine , endocrinology , cholecystokinin , ceruletide , pancreas , gastrointestinal hormone , pancreatic disease , exocrine secretion , secretion , receptor , peptide hormone
AbstractBackground: Pancreastatin (PST) is an inhibitor of pancreatic exocrine secretion in vivo but not in vitro , which suggests that the inhibitory effect of PST is indirect, that is, not mediated by a specific receptor on pancreatic acinar cells. In this study, we investigated the effects of PST on pancreatic exocrine secretion and local pancreatic blood flow in anaesthetized rats to elucidate the participation of PST in indirect regulation of pancreatic exocrine function through blood supply.Methods: Pancreastatin (100, 200 or 500 pmol/kg per h) was administered intravenously under background infusion of cerulein (0.5 μg/kg per h), a cholecystokinin analogue. Pancreatic exocrine secretion was monitored by volume and protein output of the pancreatic juice and local pancreatic blood flow was measured by the hydrogen gas clearance method.Results: Pancreastatin significantly reduced cerulein‐induced local pancreatic blood flow in a dose‐dependent manner. Pancreatic exocrine secretion was also reduced significantly by PST dose‐dependently. Pancreastatin did not change systemic blood pressure. These results suggested that the reduction of pancreatic blood flow is associated with the reduction of pancreatic exocrine secretion.Conclusions: We conclude that the mechanism of PST‐induced inhibition of pancreatic exocrine secretion is, at least, partly mediated by the reduction of local pancreatic blood flow through blockade, caused by the action of cerulein on pancreatic blood flow. © 1999 Blackwell Science Asia Pty Ltd