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Proliferation of hepatic metastases of colorectal carcinoma: Relationship to primary tumours and prognosis after hepatic resection
Author(s) -
Nanashima Atsushi,
Yamaguchi Hiroyuki,
Shibasaki Shinichi,
Sawai Terumitsu,
Yasutake Toru,
Tsuji Takashi,
Nakagoe Tohru,
Ayabe Hiroyoshi
Publication year - 1999
Publication title -
journal of gastroenterology and hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.214
H-Index - 130
eISSN - 1440-1746
pISSN - 0815-9319
DOI - 10.1046/j.1440-1746.1999.01805.x
Subject(s) - medicine , metastasis , colorectal cancer , pathology , hepatectomy , carcinoma , oncology , primary tumor , gastroenterology , resection , cancer , surgery
In this study, we determined the proliferation indices of liver metastatic tumours originating from colorectal carcinomas using Ki67 and argyrophil nucleolar organizer region associated proteins (AgNOR) stain. We examined the primary and metastatic tumours in 27 patients with liver metastasis and eight cases with non‐metastatic colorectal carcinoma as a control. The number of AgNOR dots in metastatic tumours was significantly higher than in the respective primary tumours of the metastasis group or in non‐metastatic colorectal carcinomas. The Ki67 labelling index was similar in all groups. The Ki67 labelling index and AgNOR counts did not correlate with each other. There was no significant relationship between proliferation indices and the duration of the disease‐free period following hepatic resection for metastases or with prognosis after hepatectomy. We conclude that Ki67 and AgNOR are not useful indicators of prognosis in patients who undergo operation for liver metastasis of colorectal carcinomas.