Premium
Does recycling in germinal centres exist?
Author(s) -
MeyerHermann Michael
Publication year - 2002
Publication title -
immunology and cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.999
H-Index - 104
eISSN - 1440-1711
pISSN - 0818-9641
DOI - 10.1046/j.1440-1711.2002.01052.x
Subject(s) - germinal center , selection (genetic algorithm) , population , process (computing) , mathematical optimization , test (biology) , mathematics , computer science , operations research , mathematical economics , biology , artificial intelligence , genetics , demography , sociology , ecology , b cell , antibody , operating system
A general criterion is formulated to decide if the recycling of B cells exists in germinal centre (GC) reactions. The criterion is independent of the selection and affinity maturation process and based solely on total centroblast population arguments. An experimental test is proposed to verify whether the criterion is fulfilled.