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Morphological Changes in the Sciatic Nerve of Diabetic Rats Treated with Low Molecular Weight Heparin OP 2123/Parnaparin
Author(s) -
Artico M.,
Massa R.,
Cavallotti D.,
Franchitto S.,
Cavallotti C.
Publication year - 2002
Publication title -
anatomia, histologia, embryologia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.34
H-Index - 35
eISSN - 1439-0264
pISSN - 0340-2096
DOI - 10.1046/j.1439-0264.2002.00373.x
Subject(s) - sciatic nerve , microangiopathy , diabetes mellitus , medicine , diabetic neuropathy , endocrinology , heparin , low molecular weight heparin
Summary This study points out the early alterations that affect the sciatic nerve of rats with experimentally induced diabetes. It emphasizes the advantages deriving from treatment with low molecular weight heparin (LMWH) OP 2123/parnaparin and correlates these findings with observations emerging from a review of the relevant literature. In fact, the number and diameter of the capillaries within the sciatic nerve of diabetic rats appear to be increased consistent with a microangiopathy (the main characteristic of which is the fragility of new vessels), that is related to the evolution of diabetes in humans and animals. Our results suggest a possible therapeutic role for OP 2123/parnaparin in both diabetic neuropathy and microangiopathy, frequent complications of diabetes.