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Platelet‐specific antibodies in female blood donors after pregnancy
Author(s) -
Schnaidt,
Wernet
Publication year - 2000
Publication title -
transfusion medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.471
H-Index - 59
eISSN - 1365-3148
pISSN - 0958-7578
DOI - 10.1046/j.1365-3148.2000.00234.x
Subject(s) - pregnancy , antibody , platelet , medicine , obstetrics , isoantibodies , immunology , gynecology , biology , genetics
Sera of 500 female blood donors after pregnancy were tested for platelet‐specific antibodies (HPA‐1, 3, 5) using the MAIPA assay. Twenty‐one sera (4.2%) were found to be positive: four anti‐HPA‐1a, one anti‐HPA‐5a and 16 anti‐HPA‐5b. Sera were positive up to 30 years after the last pregnancy. All women with antibodies were HLA‐DR52 positive and 79% of the women with anti‐HPA‐5b were HLA‐DR6 positive.