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Serious adverse events after HPA‐incompatible platelet transfusions in an alloimmunized patient with leukaemia
Author(s) -
Koponen,
Kekomäki
Publication year - 1998
Publication title -
transfusion medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.471
H-Index - 59
eISSN - 1365-3148
pISSN - 0958-7578
DOI - 10.1046/j.1365-3148.1998.00152.x
Subject(s) - platelet , medicine , chills , platelet transfusion , immunology , adverse effect , neonatal alloimmune thrombocytopenia , human leukocyte antigen , plateletpheresis , antigen , isoantibodies , apheresis , pregnancy , biology , fetus , genetics
We describe an alloimmunized female patient who developed serious adverse reactions when receiving HPA‐incompatible platelet transfusions. She had received 13 transfusions with random platelets before the first allergic reactions. Antibodies against both the human leucocyte antigens (HLA) and several human platelet antigens (HPA) were detected at the time of transfusions. When the patient received HLA‐ and HPA‐compatible platelets, no reactions followed the transfusions and platelet count increments were good. When she was transfused with platelets from donors with one foreign HLA antigen, her reactions were fever, chills and headache and the response to platelet transfusions was poor. When the platelets were HLA compatible but HPA incompatible, the reactions were repeatedly rapid pulse, shortness of breath, tightness of chest and wheezing interpretable as anaphylactoid reactions. Platelet count increments were satisfactory. When rare side‐effects occur after transfusion, detailed immunohaematological studies are indicated.