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In Vivo Activation of T‐Cell Induction into the Primed Phenotype and Programmed Cell Death by Staphylococcal Enterotoxin B
Author(s) -
AROEIRA L. S.,
MORENO M. C.,
MARTINEZA C.
Publication year - 1996
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1046/j.1365-3083.1996.d01-75.x
Subject(s) - programmed cell death , biology , t cell , population , apoptosis , microbiology and biotechnology , phenotype , immunology , immune system , gene , medicine , genetics , environmental health
The authors demonstrate that SEB immunization activates Vβ8 + T cells and induces the acquisition of the primed phenotype as defined previously by low MEL‐14 and high Pgp‐1 expression. SEB‐activated spleen CD4 + and CD8Vβ8 + T cells have different population dynamics and regulate the expression of MEL‐14 and Pgp‐1 differentially, suggesting that the SEB‐MHC class II complex preferentially activates CD4Vβ8 + T cells. Interestingly, at day 3 after SEB immunization, Vβ8 + T cells expressing low, but not high, levels of MEL‐14 undergo apoptosis, indicating that T‐cell activation is a prerequisite for triggering programmed cell death. These results might help to trace antigen‐reactive cells to the activated or primed pool, as well as to identify those cells which will undergo programmed cell death.