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A comparison of the in vitro cytotoxicity of two root canal sealers
Author(s) -
Öztan M. Dartar,
Yilmaz Ş.,
Kalayci A.,
Zai̇moğlu L.
Publication year - 2003
Publication title -
journal of oral rehabilitation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.991
H-Index - 93
eISSN - 1365-2842
pISSN - 0305-182X
DOI - 10.1046/j.1365-2842.2003.01053.x
Subject(s) - cytotoxicity , hemocytometer , silicone , epoxy , chemistry , root canal , dentistry , mtt assay , in vitro , medicine , biochemistry , organic chemistry
summary The purpose of this study was to compare the cytotoxicity of an epoxy resin‐based sealer (AH Plus) and a silicone‐based sealer (Roeko Seal Automix, RSA). Cytotoxicity was assessed using the MTT assay for mitochondrial enzyme activity and haemocytometer viable cell counting after 24, 48 and 72‐h exposure to L929 cells. AH Plus and RSA showed no statistically significant difference in the degree of toxicity. Both sealers had a low toxic influence on the cells during the experimental period. This study indicates that epoxy resin‐based sealer AH Plus and the silicone‐based sealer RSA have similar levels of cytotoxicity to mouse fibroblasts.