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The adverse effect of commercial dentine‐bonding systems on the skin of guinea pigs
Author(s) -
Kazuyuki Katsuno,
Atsufumi Manabe,
Ayako Kurihara,
Kazuo Itoh,
Hisashi Hisamitsu,
Sadao Wakumoto,
Takemi Yoshida
Publication year - 1998
Publication title -
journal of oral rehabilitation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.991
H-Index - 93
eISSN - 1365-2842
pISSN - 0305-182X
DOI - 10.1046/j.1365-2842.1998.00211.x
Subject(s) - irritation , methacrylate , skin irritation , dentistry , contact dermatitis , materials science , chemistry , dermatology , medicine , composite material , immunology , allergy , copolymer , polymer
It was widely known that 2‐hydroxyethyl methacrylate (2‐HEMA) can cause contact dermatitis. Commercially available dentine primers and dentine bonding agents that contain 2‐HEMA are widely used. The purpose of this study was to investigate the cumulative irritation and delayed hypersensitivity caused by commercial dentine bonding systems when applied to the skin of guinea pigs. We have concluded that almost no dentine bonding systems cause cumulative irritation, but some commercially available dentine bonding systems may produce delayed hypersensitivity.