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The Q/E27 polymorphism in the β 2 ‐adrenoceptor gene is associated with increased body weight and dyslipoproteinaemia involving triglyceride‐rich lipoproteins
Author(s) -
Ehrenborg E.,
Skogsberg J.,
Ruotolo G.,
Large V.,
Eriksson P.,
Arner P.,
Hamsten A.
Publication year - 2000
Publication title -
journal of internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.625
H-Index - 160
eISSN - 1365-2796
pISSN - 0954-6820
DOI - 10.1046/j.1365-2796.2000.00669.x
Subject(s) - endocrinology , medicine , body mass index , triglyceride , allele , very low density lipoprotein , population , cholesterol , lipoprotein , genetics , biology , gene , environmental health
. Ehrenborg E, Skogsberg J, Ruotolo G, Large V, Eriksson P, Arner P, Hamsten A (Karolinska Hospital, Stockholm, and Huddinge University Hospital, Huddinge, Sweden; and Istuto Scientifico H San Raffaele, Milano, Italy). The Q/E27 polymorphism in the β 2 ‐adrenoceptor gene is associated with increased body weight and dyslipoproteinaemia involving triglyceride‐rich lipoproteins. J Intern Med 2000; 247: 651–656. Objectives. To investigate whether a substitution of glutamine by glutamic acid at amino acid position 27 (Q/E27) and an arginine to glycine transition at amino acid 16 (R/G16) in the β 2 ‐adrenoceptor gene are associated with lipid and lipoprotein disturbances and/or increased body weight in men. Design. Population‐based study. Setting. Department of medicine at a university hospital. Subjects. A total of 180 healthy men, aged 30–45 years, were recruited at random from a register containing all permanent residents in Stockholm County (response rate of 70%). Main outcome measures. Frequency of β 2 ‐adrenoceptor genotypes and alleles in relation to plasma lipid and lipoprotein levels and body mass index. Results. Individuals carrying the E27 allele and/or the G16 allele had significantly higher body mass index (BMI). Furthermore, carriers of the E27 allele had significantly higher plasma concentrations of cholesterol, triglycerides, VLDL cholesterol and VLDL triglycerides than did subjects homozygous for the Q allele. Conclusion. The E27 allele of the β 2 ‐adrenoceptor gene is associated with slightly to moderately elevated BMI and dyslipoproteinaemia involving triglyceride‐rich lipoproteins in healthy younger and middle‐aged men.