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Establishment of orally‐administered Lactobacillus gasseri SBT2055SR in the gastrointestinal tract of humans and its influence on intestinal microflora and metabolism
Author(s) -
Fujiwara S.,
Seto Y.,
Kimura A.,
Hashiba H.
Publication year - 2001
Publication title -
journal of applied microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.889
H-Index - 156
eISSN - 1365-2672
pISSN - 1364-5072
DOI - 10.1046/j.1365-2672.2001.01251.x
Subject(s) - lactobacillus gasseri , gastrointestinal tract , microbiology and biotechnology , metabolism , lactobacillus , biology , human gastrointestinal tract , feces , bacteria , biochemistry , genetics
Aims: To investigate the fate of a streptomycin–rifampicin‐resistant variant of Lactobacillus gasseri SBT2055 (LG2055SR) and the influence of its oral administration on the composition and metabolism of the intestinal microflora. Methods and Results: Intestinal passage of LG2055SR was monitored by a combination of selection with antibiotics and identification by a randomly amplified polymorphic DNA (RAPD)‐PCR method. Composition of intestinal microflora was analysed by the method developed by Mitsuoka et al . (1965, 1974). Establishment of orally‐administered LG2055SR in the human intestine was confirmed in this study. LG2055SR ingestion specifically lowered faecal populations of Staphylococcus and faecal contents of p‐cresol. Conclusions: LG2055SR and its parent strain, LG2055, are considered to be appropriate candidates for probiotics. Significance and Impact of the Study: It is clarified that LG2055SR has the ability to establish in the human gastrointestinal tract and alters the composition and metabolism of the intestinal microflora and physical characteristics of faeces.