Premium
Delivery of endostatin in experimental cancer therapy
Author(s) -
R. Sorensen Dag,
Read TracyAnn
Publication year - 2002
Publication title -
international journal of experimental pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.671
H-Index - 72
eISSN - 1365-2613
pISSN - 0959-9673
DOI - 10.1046/j.1365-2613.2002.00240.x
Subject(s) - endostatin , angiogenesis , angiogenesis inhibitor , cancer research , cancer , clinical trial , medicine , chemistry
Summary. Endostatin, the 20 kDa C‐terminal fragment of collagen XVIII, has been shown to be an effective inhibitor of tumour angiogenesis and growth in different experimental systems and is currently in Phase II/III clinical trials. One challenging aspect of anti‐angiogenic treatment is the mode of delivery of the active compound. In this paper we review some of the basic knowledge of endostatin and look specifically into the different possible ways in which endostatin may be administered.