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A new view of V(D)J recombination
Author(s) -
Gellert Martin
Publication year - 1996
Publication title -
genes to cells
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.912
H-Index - 115
eISSN - 1365-2443
pISSN - 1356-9597
DOI - 10.1046/j.1365-2443.1996.22023.x
Subject(s) - biology , rag2 , recombination activating gene , v(d)j recombination , recombination , dna , cleavage (geology) , gene , gene rearrangement , genetics , dna repair , genetic recombination , microbiology and biotechnology , computational biology , paleontology , fracture (geology)
The DNA rearrangement that assembles antibody and T cell receptor genes is beginning to be understood. New work shows that the first step is a site‐specific cleavage which can be performed by purified RAG1 and RAG2 proteins. The later steps largely overlap with the repair of radiation‐induced DNA double‐strand breaks, as indicated by the identity of several newly cloned factors. These developments open the way for a thorough biochemical study of V(D)J recombination.