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Purpura and leg ulcers in a patient with cryoglobulinaemia, non‐Hodgkin's lymphoma, and antiphospholipid syndrome
Author(s) -
Andrejevic S.,
BonaciNikolic B.,
Bukilica M.,
Milivojevic G.,
Basanovic J.,
Nikolic M. M.
Publication year - 2003
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1046/j.1365-2230.2003.01189.x
Subject(s) - medicine , cryoprecipitate , antiphospholipid syndrome , lupus anticoagulant , cryoglobulins , lymphoma , cryoglobulinemia , discoid lupus erythematosus , lymphoproliferative disorders , immunology , purpura (gastropod) , rituximab , pathology , antibody , dermatology , lupus erythematosus , platelet , ecology , biology , hepatitis c virus , virus
Summary We report a 69‐year‐old Caucasian female with non‐Hodgkin's lymphoma who subsequently developed leg ulcers as a manifestation of the antiphospholipid syndrome. Investigations revealed a mixed cryoglobulinaemia with monoclonal IgM‐κ and antiphospholipid activity with anticardiolipin antibodies, antimitochondrial type M5 antibodies and lupus anticoagulant. Significantly increased concentration of anticardiolipin antibodies was detected in the cryoprecipitate. Our case illustrates a connection between cryoglobulinaemia and lymphoproliferative and autoimmune disorders. Both cryoglobulins and anticardiolipin antibodies could participate in the vascular damage. Cutaneous manifestations in the presence of these disorders associated with non‐Hodgkin's lymphoma have not been described previously.